Tumor Necrosis Factor Receptor–Associated Periodic Syndrome
نویسندگان
چکیده
منابع مشابه
[Tumor necrosis factor receptor-associated periodic syndrome].
Tumoral necrosis factor receptor-associated periodic syndrome (TRAPS) is an autosomal dominantly inherited disease belonging to the hereditary periodic fever syndromes, which are the main subgroup among systemic autoinflammatory diseases. TRAPS is characterized by prolonged and recurrent inflammatory attacks associated with fever and an acute phase reaction. Articular, cutaneous, ocular and abd...
متن کاملModified regimen of etanercept for tumor necrosis factor receptor associated periodic syndrome (TRAPS) like illness.
BACKGROUND TRAPS, an autosomal dominant autoinflammatory disorder occurs due to mutations of the TNFRSF1A gene. Mutation negative TRAPS (TRAPS like illness) is also known. Anti TNF molecules (etanercept) is the mainstay of therapy. CASE CHARACTERISTICS A 11-year-old boy with a 5 year clinical profile indicative of a TRAPS like illness and with negative mutation studies is described. He has be...
متن کاملSuccessful treatment of tumor necrosis factor receptor-associated periodic syndrome (TRAPS) with tocilizumab: A case report.
Tumor necrosis factor receptor-associated periodic syndrome (TRAPS) is an autosomal dominant autoinflammatory disease linked to chromosome 12p13 and, more specifically, with mutations within the tumor necrosis factor receptor superfamily, member 1A gene (TNFRSF1A gene). It is characterized by the presence of fever, abdominal pain, myalgia, arthralgia or arthritis, and skin rash. In this report,...
متن کاملElevated CD16 expression by monocytes from patients with tumor necrosis factor receptor-associated periodic syndrome.
OBJECTIVE Tumor necrosis factor receptor-associated periodic syndrome (TRAPS) is an inherited autosomal-dominant autoinflammatory condition caused by mutations in the ectodomain of the 55-kd tumor necrosis factor (TNF) receptor superfamily 1A. Proinflammatory blood monocytes with the phenotype CD14+,CD16+,HLA-DR++ are a major source of TNF, and the number of such monocytes is increased during i...
متن کاملFirst report of rapidly progressive glomerulonephritis in tumor necrosis factor receptor-associated periodic syndrome.
Tumor necrosis factor receptor–associated periodic syndrome (TRAPS; MIM no. 142680), the most common autosomal-dominant recurrent fever, is caused by mutations in the gene encoding tumor necrosis factor receptor superfamily 1A (TNFRSF1A) on chromosome 12p13 (1). It is characterized by periodic fever, arthralgia, myalgia, abdominal pain, serositis, and skin rash. These symptoms are partially exp...
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ژورنال
عنوان ژورنال: Archives of Dermatology
سال: 2000
ISSN: 0003-987X
DOI: 10.1001/archderm.136.12.1487